Non-Hodgkin lymphoma of childhood

Abstract

Non-Hodgkin lymphoma (NHL) refers to a group of diverse tumors derived from cells of lymphocytic lineage. They occur as clonal proliferations of single cells at any stage of lymphocyte development. In contrast to adult NHL, childhood NHL are typically high grade, tend to present as advanced disease, yet with intensive multiagent chemotherapy, the outcome is favorable. Active research is aimed at minimizing late effects in childhood cancer survivors, studying biological differences, and identifying high-risk populations who may benefit from novel targeted therapies.