Studies of high-altitude populations, and in particular of maladapted subgroups, may provide important insight into underlying mechanisms involved in the pathogenesis of hypoxemia-related disease in general. Chronic mountain sickness (CMS) is a major public health problem in mountainous regions of the world affecting many millions of high-altitude dwellers. It is characterized by exaggerated chronic hypoxemia, erythrocytosis, and mild pulmonary hypertension. In later stages these patients often present with right heart failure and are predisposed to systemic cardiovascular disease, but the underlying mechanisms are poorly understood. Here, we present recent new data providing insight into underlying mechanisms that may cause these complications.
CITATION STYLE
Rimoldi, S. F., Rexhaj, E., Villena, M., Salmon, C. S., Allemann, Y., Scherrer, U., & Sartori, C. (2016). Novel insights into cardiovascular regulation in patients with chronic mountain sickness. In Advances in Experimental Medicine and Biology (Vol. 903, pp. 83–100). Springer New York LLC. https://doi.org/10.1007/978-1-4899-7678-9_6
Mendeley helps you to discover research relevant for your work.