Rapid T1quantification based on 3D phase sensitive inversion recovery

Abstract

Background: In Contrast Enhanced Magnetic Resonance Imaging fibrotic myocardium can be distinguished from healthy tissue using the difference in the longitudinal T1relaxation after administration of Gadolinium, the so-called Late Gd Enhancement. The purpose of this work was to measure the myocardial absolute T1post-Gd from a single breath-hold 3D Phase Sensitivity Inversion Recovery sequence (PSIR). Equations were derived to take the acquisition and saturation effects on the magnetization into account.Methods: The accuracy of the method was investigated on phantoms and using simulations. The method was applied to a group of patients with suspected myocardial infarction where the absolute difference in relaxation of healthy and fibrotic myocardium was measured at about 15 minutes post-contrast. The evolution of the absolute R1relaxation rate (1/T1) over time after contrast injection was followed for one patient and compared to T1mapping using Look-Locker. Based on the T1maps synthetic LGE images were reconstructed and compared to the conventional LGE images.Results: The fitting algorithm is robust against variation in acquisition flip angle, the inversion delay time and cardiac arrhythmia. The observed relaxation rate of the myocardium is 1.2 s-1, increasing to 6 - 7 s-1after contrast injection and decreasing to 2 - 2.5 s-1for healthy myocardium and to 3.5 - 4 s-1for fibrotic myocardium. Synthesized images based on the T1maps correspond very well to actual LGE images.Conclusions: The method provides a robust quantification of post-Gd T1relaxation for a complete cardiac volume within a single breath-hold. © 2010 Warntjes et al; licensee BioMed Central Ltd.