Three new myrsinol diterpenes from Euphorbia prolifera and their neuroprotective activities

Abstract

Three new myrsinol diterpenes were isolated from the roots of Euphorbia prolifera. Their structures were elucidated as 2α-O-isobutyryl-3β, 5α,7β,10,15β- penta-O-acetyl-14α-O-benzoyl-10,18- dihydromyrsinol (1), 2α-O-isobutyryl-3β-O-propionyl- 5α,7β,10,15β-tetra-O-acetyl-10,18-dihydromyrsinol (2), and 2α,14α-di-O-benzoyl- 3β,5α,7β,10,15β-penta-O- acetyl-10,18-dihydromyrsinol (3) on the basis of spectroscopic data analyses (IR, ESI-MS, HR-ESI-MS, and 1D and 2D NMR). Their neuroprotective activities were evaluated and compounds 1 and 2 showed neuroprotective effects against MPP+-induced neuronal cell death in SH-SY5Y cells.