Prognostic factors in canine appendicular osteosarcoma - a meta-analysis

94Citations
Citations of this article
207Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Background: Appendicular osteosarcoma is the most common malignant primary canine bone tumor. When treated by amputation or tumor removal alone, median survival times (MST) do not exceed 5 months, with the majority of dogs suffering from metastatic disease. This period can be extended with adequate local intervention and adjuvant chemotherapy, which has become common practice. Several prognostic factors have been reported in many different studies, e.g. age, breed, weight, sex, neuter status, location of tumor, serum alkaline phosphatase (SALP), bone alkaline phosphatase (BALP), infection, percentage of bone length affected, histological grade or histological subtype of tumor. Most of these factors are, however, only reported as confounding factors in larger studies. Insight in truly significant prognostic factors at time of diagnosis may contribute to tailoring adjuvant therapy for individual dogs suffering from osteosarcoma. The objective of this study was to systematically review the prognostic factors that are described for canine appendicular osteosarcoma and validate their scientific importance.Results: A literature review was performed on selected studies and eligible data were extracted. Meta-analyses were done for two of the three selected possible prognostic factors (SALP and location), looking at both survival time (ST) and disease free interval (DFI). The third factor (age) was studied in a qualitative manner. Both elevated SALP level and the (proximal) humerus as location of the primary tumor are significant negative prognostic factors for both ST and DFI in dogs with appendicular osteosarcoma. Increasing age was associated with shorter ST and DFI, however, was not statistically significant because information of this factor was available in only a limited number of papers.Conclusions: Elevated SALP and proximal humeral location are significant negative prognosticators for canine osteosarcoma. © 2012 Boerman et al.; licensee BioMed Central Ltd.

References Powered by Scopus

The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis

625Citations
N/AReaders
Get full text

Cisplatin: A review of toxicities and therapeutic applications

383Citations
N/AReaders
Get full text

Therapy for osteosarcoma in dogs with intravenous injection of liposome-encapsulated muramyl tripeptide

198Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Canine osteosarcoma: A naturally occurring disease to inform pediatric oncology

174Citations
N/AReaders
Get full text

Comparison of carboplatin and doxorubicin-based chemotherapy protocols in 470 dogs after amputation for treatment of appendicular osteosarcoma

118Citations
N/AReaders
Get full text

Bones and Joints

96Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Boerman, I., Selvarajah, G. T., Nielen, M., & Kirpensteijn, J. (2012). Prognostic factors in canine appendicular osteosarcoma - a meta-analysis. BMC Veterinary Research, 8. https://doi.org/10.1186/1746-6148-8-56

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 73

67%

Researcher 22

20%

Professor / Associate Prof. 13

12%

Lecturer / Post doc 1

1%

Readers' Discipline

Tooltip

Veterinary Science and Veterinary Medic... 76

55%

Medicine and Dentistry 39

28%

Agricultural and Biological Sciences 18

13%

Biochemistry, Genetics and Molecular Bi... 5

4%

Article Metrics

Tooltip
Mentions
News Mentions: 5
Social Media
Shares, Likes & Comments: 5

Save time finding and organizing research with Mendeley

Sign up for free