Aims: Our study addressed potential associations between fatty liver and small, dense low-density lipoprotein cholesterol (sd-LDL-C) levels using a cross-sectional analysis. Methods: We enrolled 476 male subjects. Serum sd-LDL-C concentrations were determined using precipitation assays. Results: Subjects were divided into four groups based on triglyceride (TG) and LDL-C levels: A, TG<150 mg/dl and LDL-C<140 mg/dl; B, TG<150 mg/dl and LDL-C ≥ 140 mg/dl; C, TG ≥ 150 mg/dl and LDL-C<140 mg/dl; and D, TG ≥150 mg/dl and LDL-C ≥ 140 mg/dl. sd-LDL-C levels and the prevalence of fatty liver were significantly higher in groups B, C, and D than in group A. Subjects were also categorized into four groups based on serum sd-LDL-C levels; the prevalence of fatty liver significantly increased with increasing sd-LDL-C levels. Additionally, logistic regression analysis revealed an independent association between sd-LDL-C concentrations and fatty liver using such potential confounders as obesity and hyperglycemia as variables independent of elevated TG or LDL-C levels. Conclusions: Fatty liver is a significant determinant of serum sd-LDL-C levels independent of the presence of obesity or hyperglycemia. Fatty liver may alter hepatic metabolism of TG and LDL-C, resulting in increased sd-LDL-C levels. © 2012 Hosoyamada et al.; licensee BioMed Central Ltd.
CITATION STYLE
Hosoyamada, K., Uto, H., Imamura, Y., Hiramine, Y., Toyokura, E., Hidaka, Y., … Tsubouchi, H. (2012). Fatty liver in men is associated with high serum levels of small, dense low-density lipoprotein cholesterol. Diabetology and Metabolic Syndrome, 4(1). https://doi.org/10.1186/1758-5996-4-34
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