Abstract
Background: cytb5 modulates catalysis performed by cytsP450, in vivo and in vitro. Results: The structure of full-length cytb5 was solved by NMR, and the cytP450-binding site on cytb5 was identified by mutagenesis and NMR. Conclusion: A model of the cytb5-cytP450 complex is presented. Addition of a substrate strengthens the cytb 5-cytP450 interaction. Significance: The cytb5-cytP450 complex structure will help unravel the mechanism by which cytb5 regulates catalysis by cytP450. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
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CITATION STYLE
Ahuja, S., Jahr, N., Im, S. C., Vivekanandan, S., Popovych, N., Le Clair, S. V., … Ramamoorthy, A. (2013). A model of the membrane-bound cytochrome b5-cytochrome P450 complex from NMR and mutagenesis data. Journal of Biological Chemistry, 288(30), 22080–22095. https://doi.org/10.1074/jbc.M112.448225
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