Postnatal development- and age-related changes in DNA-methylation patterns in the human genome

40Citations
Citations of this article
81Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Alterations in DNA methylation have been reported to occur during development and aging; however, much remains to be learned regarding post-natal and age-associated epigenome dynamics, and few if any investigations have compared human methylome patterns on a whole genome basis in cells from newborns and adults. The aim of this study was to reveal genomic regions with distinct structure and sequence characteristics that render them subject to dynamic post-natal developmental remodeling or age-related dysregulation of epigenome structure. DNA samples derived from peripheral blood monocytes and in vitro differentiated dendritic cells were analyzed by methylated DNA Immunoprecipitation (MeDIP) or, for selected loci, bisulfite modification, followed by next generation sequencing. Regions of interest that emerged from the analysis included tandem or interspersed-tandem gene sequence repeats (PCDHG, FAM90A, HRNR, ECEL1P2), and genes with strong homology to other family members elsewhere in the genome (FZD1, FZD7 and FGF17). Our results raise the possibility that selected gene sequences with highly homologous copies may serve to facilitate, perhaps even provide a clock-like function for, developmental and age-related epigenome remodeling. If so, this would represent a fundamental feature of genome architecture in higher eukaryotic organisms. Published by Oxford University Press 2012.2012This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. © Published by Oxford University Press 2012.

References Powered by Scopus

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

16918Citations
N/AReaders
Get full text

Epigenetic regulation of gene expression: How the genome integrates intrinsic and environmental signals

5079Citations
N/AReaders
Get full text

The fundamental role of epigenetic events in cancer

4942Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Influence of environmental exposure on human epigenetic regulation

193Citations
N/AReaders
Get full text

Mechanisms underlying T cell immunosenescence: Aging and cytomegalovirus infection

155Citations
N/AReaders
Get full text

Genetics and epigenetics of aging and longevity

147Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Salpea, P., Russanova, V. R., Hirai, T. H., Sourlingas, T. G., Sekeri-Pataryas, K. E., Romero, R., … Howard, B. H. (2012). Postnatal development- and age-related changes in DNA-methylation patterns in the human genome. Nucleic Acids Research, 40(14), 6477–6494. https://doi.org/10.1093/nar/gks312

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 32

54%

Researcher 22

37%

Professor / Associate Prof. 4

7%

Lecturer / Post doc 1

2%

Readers' Discipline

Tooltip

Agricultural and Biological Sciences 32

58%

Biochemistry, Genetics and Molecular Bi... 13

24%

Medicine and Dentistry 8

15%

Computer Science 2

4%

Save time finding and organizing research with Mendeley

Sign up for free