Investigation of the genetic basis of hyperuricaemia is a subject of intense interest. However, clinical studies commonly include hyperuricaemic patients without distinguishing between 'over-producers' or 'underexcretors' of urate. The statistical power of studies of genetic polymorphisms of genes encoding renal urate transporters is diluted if 'over-producers' of uric acid are included. We propose that lower than normal fractional renal clearance of urate is a better inclusion criterion for these studies. We also propose that a single daytime spot urine sample for calculation of fractional renal clearance of urate should be preferred to calculation from 24-hour urine collections. © 2010 BioMed Central Ltd.
CITATION STYLE
Indraratna, P. L., Stocker, S. L., Williams, K. M., Graham, G. G., Jones, G., & Day, R. O. (2010, December 16). A proposal for identifying the low renal uric acid clearance phenotype. Arthritis Research and Therapy. https://doi.org/10.1186/ar3191
Mendeley helps you to discover research relevant for your work.