Impact of STAT1 and CD8+ T cells on the antineoplastic activity of lapatinib and doxorubicin against spontaneous mammary tumors

Abstract

We have recently demonstrated that CD8+ T cells provide a critical contribution to the antineoplastic activity of 2 chemotherapeutic agents, i.e., doxorubicin and lapatinib, in a model of spontaneous mammary carcinogenesis. The activation of CD8+ T cells and their recruitment to neoplastic lesions turned out to rely on signal transduction and activator of transcription 1 (STAT1). Accordingly, STAT1-deficient tumor-bearing mice exhibited an impaired response to chemotherapy. © 2013 Landes Bioscience.