The Effectiveness of Autologous Platelet-Rich Plasma (PRP) in the Therapy of Infertile Men with Non-Abstractive Azoospermia

Abstract

Introduction: Non-obstructive azoospermia is a cause of male infertility and despite the advancement in gynecology it is still one of the most challenging conditions to treat. One of the possible treatments for this condition may be Platelet-Rich-Plasma (PRP) due to its well-known regenerative potential. Objectives: To evaluate the effectiveness of autologous PRP in the therapy of infertile men with nonobstructive Azoospermia. Methods: Seventy-one patients received ½ ml PRP in each testicle which was prepared by centrifuging patient’s own blood. FNA parameters and FSH levels of the patients were measured before and after the procedure. Testosterone level was measured before the procedure. All the required data for the study was collected retrospectively from the hospital records. Results: A couple of NOA cases developed normal spermatogenesis. Post-procedure FSH was higher than preprocedural FSH (MD 1.737, p .560). Patients with spermatocytes in the initial FNA report showed a lower percentage of azoospermia than their counterparts (11.4% vs 44.4%). Conclusion: Numerous studies have proven PRP to have a statistically significant level of regenerative potential in different branches of medicine. PRP therapy has been successful for the treatment of some causes of female infertility. The treatment potential of PRP for male infertility may not be underestimated.