Supported reagents: Opportunities and limitations

Abstract

The in vitro testing of collections of compounds has reached a stage where more compounds can be tested than can be synthesised. To keep up with this demand chemists have turned towards investigating parallel synthesis methods, which reduce the time spent in the work-up of a reaction. The vast literature regarding solution-phase chemistry and simple reaction monitoring has encouraged chemists to consider synthesis in solution-phase with the aid of supported reagents. Although the first developments were published over three decades ago, only recently has their appeal reached a wider audience. 1. Introduction. 2. Oxidations using supported reagents. 3. Reductions using supported reagents. 4. Supported triphenylphosphine. 5. Supported nucleophiles. 6. Supported bases. 7. Supported coupling reagents. 8. Supported catalysts. 9. Multi-step synthesis using supported reagents. 10. Conclusions and outlook.