Wenn Kinder und Jugendliche körperlich chronisch krank sind

Abstract

{AbstractBackground}Association of rs1344706 in the {ZNF804A} gene (2q32.1) with schizophrenia was first reported in a genome wide scan conducted in a sample of 479 cases and replicated in 6666 cases. Subsequently, evidence by replication was obtained in several samples with European- and Asian ancestral background.MethodsWe report ascertainment, clinical characterization, quality control, and determination of ancestral background of a case control sample from Indonesia, comprising 1067 cases and 1111 ancestry matched controls. Genotyping was performed using a fluorescence-based allelic discrimination assay ({TaqMan} {SNP} genotyping assay) and a newly designed {PCR–RFLP} assay for confirmation of rs1344706 genotypes.ResultsWe confirmed association of the T-allele of rs1344706 with schizophrenia in a newly ascertained sample from Indonesia with Southeast Asian ancestral background (P = 0.019, {OR} = 1.155, 95%, {CI} 1.025–1.301). In addition, we studied several {SNPs} in the vicinity of rs1344706, for which nominally significant results had been reported. None of the association P values of the additional {SNPs} exceeded that of rs1344706.ConclusionWe provide additional evidence for association of the {ZNF804A} gene with schizophrenia. We conclude that rs1344706 or a yet unknown polymorphism in linkage disequilibrium is also involved in conferring susceptibility to schizophrenia in samples with different (Asian) ancestral backgrounds.