Towards radiotherapy enhancement and real time tumor radiation dosimetry through 3D imaging of gold nanoparticles using XFCT

Abstract

To enhance the efficiency of radiotherapy, a promising strategy consists in tumor exposure simultaneously to ionizing radiation (IR) and gold nanoparticles (GNPs). Indeed, when exposed to the radiation beam, these GNPs exhibit a photoelectric effect that generates reactive oxygen species (ROS) within the tumor and enhances the direct IR related deleterious effects. The measurement of this photoelectric effect thanks to an additional detector could give new insight for in vivo quantification and distribution of the GNPs in the tumor and more importantly for measuring the precise dose deposition. As a first step towards such a challenge, we present here materials and methods designed for detecting and measuring very low concentrations of GNPs in solution and for performing 3D reconstruction of small gold objects whose size is representative with respect to the considered application. A matrix image detector, whose sensitivity is first validated through the detection of few hundreds of micrograms of GNPs, is combined with a pinhole element and moved along a limited circular trajectory to acquire 2D fluorescence images of a motionless object. We implement a direct back-projection algorithm that provides a 3D image of these objects from this sparse set of data.