Von Willebrand factor antigen compared with other factors in vasculitic syndromes

33Citations
Citations of this article
15Readers
Mendeley users who have this article in their library.

Abstract

In order to analyse their role as a specific marker of vascular damage and their value in monitoring disease activity the plasma concentrations of von Willebrand factor antigen (vWFAg) and the ristocetin cofactor (RiCoF) activities were determined in 43 children with vasculitis and 20 controls. These patients were subdivided into three groups according to diagnosis: Henoch-Schonlein purpura (n=18), polyarteritis nodosa (n=16), and systemic lupus erythematosus (n=9). High concentrations of vWFAg and activities of RiCoF were found in all the patient groups. vWFAg and RiCoF returned to normal as the patients became symptom free and remained above normal in those with continuing symptoms. The amount of vWFAg did not correlate with the acute phase reactants. vWFAg acted as a specific marker of vascular damage and was useful for the monitoring of disease activity both in small vessel vasculitis and systemic necrotising arteritis.

Cite

CITATION STYLE

APA

Ates, E., Bakkaloglu, A., Saatci, U., & Soylemezoglu, O. (1994). Von Willebrand factor antigen compared with other factors in vasculitic syndromes. Archives of Disease in Childhood, 70(1), 40–43. https://doi.org/10.1136/adc.70.1.40

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free