Two new oxysporone derivatives from the fermentation broth of the endophytic plant fungus Pestalotiopsis karstenii Isolated from Stems of Camellia sasanqua

Abstract

Two new oxysporone derivatives, pestalrone A (1) and pestalrone B (2), along with two known structurally related compounds 3, 4, were from the fermentation broth of the endophytic plant fungus Pestalotiopsis karstenii isolated from stems of Camellia sasanqua. Their structures and relative configurations were elucidated by extensive spectroscopic analysis and comparison of chemical shifts with related known compounds. Compound 2 exhibited significant activities agains HeLa, HepG2 and U-251 with IC 50 values of 12.6, 31.7 and 5.4 μg/mL, respectively. © 2012 by the authors.