Antimicrobial and antileishmanial studies of novel (2E)-3-(2-chloro-6- methyl/methoxyquinolin-3-yl)-1-(aryl)prop-2-en-1-ones

Abstract

Thirty eight heterocyclic chalcones were synthesized by condensing formylquinolines with diverse methyl arylketones. The target compounds were characterized by spectroscopic techniques (NMR, IR, MS) and elemental analysis. The X-ray crystallographic study of (2E)-3-(2-chloro-6-methylquinolin-3-yl)-1- (2,3-dihydro-1,4-benzodioxin-6-yl)prop-2-en-1-one (1p) was also performed for the structure confirmation. The title compounds were screened for anti-microbial and antileishmanial activities. The compounds 1c - e, 1g, 1j - m, 1p, 1r - s, 2g, 2j - p, and 2r - s were found potentially active antileishmanial agents, while 1f - i, 1l, 1o - p, 2f - i, 2l, and 2o - p showed remarkable antibacterial activity. Only compounds 1g and 2g - h exhibited significant antifungal activity. © 2010 Pharmaceutical Society of Japan.