Stent fracture and peri-stent contrast staining after everolimus-eluting stent implantation: 5-year outcomes

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Abstract

Background: Stent fracture (SF) and peristent contrast staining (PSS) after sirolimus-eluting stent implantation are reported to be risk factors of adverse events. However, the effect of these after everolimus-eluting stent (EES) implantation on long-term outcomes remains unclear. Methods and Results: The study sample comprised 636 patients (1,081 lesions) undergoing EES implantation in 2010 and followup angiography within 1 year. The 5-year cumulative rates of target lesion revascularization (TLR) and major adverse cardiac events (MACE: a combination of all-cause death, myocardial infarction, and TLR) were compared between patients with and without SF or PSS. SF was observed in 2.7%, and PSS in 3.0%. The cumulative rates of MACE and TLR were significantly higher in the SF group than in the non-SF group (51.7% vs. 27.5% and 48.3% vs. 13.4%, respectively), but showed no significant differences between the PSS and non-PSS groups. In a landmark analysis, the rate of TLR within 1 year was significantly higher in the SF group than in the non-SF group (44.8% vs. 7.2%), but beyond 1 year showed no significant difference (6.3% vs 6.7%). Conclusions: The 5-year clinical outcomes suggested that SF after EES implantation is related to increased risk of MACE and TLR, especially within 1 year after the procedure, but PSS after EES implantation is unrelated.

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Miura, K., Tada, T., Kuwayama, A., Shimada, T., Ohya, M., Amano, H., … Kadota, K. (2017). Stent fracture and peri-stent contrast staining after everolimus-eluting stent implantation: 5-year outcomes. Circulation Journal, 81(10), 1514–1521. https://doi.org/10.1253/circj.CJ-17-0236

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