Testosterone 2% gel (Testavan®, Testarzon®) in adult male hypogonadism: a profile of its use

Abstract

Testosterone 2% (20 m/mL) transdermal gel (Testavan®, Testarzon®), is indicated to treat adult male hypogonadism, when testosterone deficiency has been confirmed by clinical features and biochemical tests. It is applied once daily using a hands-free applicator, with an initial recommended daily dosage equivalent to 23 mg testosterone, which may be increased to 46 or 69 mg/day. In clinical studies, once-daily application of Testavan 2% gel was associated with rapid and extensive absorption of testosterone, leading to normalization of testosterone levels in hypogonadal men. After application, testosterone levels achieve their peak in ≈ 2–4 h, then decrease to pre-application levels at ≈ 12 h, broadly mirroring the natural diurnal rhythm of male testosterone. Testavan 2% gel also improved sexual, physical and mental functioning, fatigue and health-related quality of life. The components of Testavan’s novel gel enhance the transdermal transfer of testosterone into the blood, allowing the application of lower doses of testosterone in smaller gel volumes relative to the application of other transdermal testosterone gels. Testavan 2% gel is applied using the applicator cap rather than by hand, reducing the potential risk of secondary transfer of testosterone.