Objective: To determine serum soluble CD30 (sCD30) levels in patients with graft versus host disease (GVHD). Methods: Serum soluble CD30 levels and IgE levels were assayed by a sensitive ELISA in 57 patients with bone marrow transplantation, and in 44 healthy controls. We analyzed the type of effector T cells in patients with GVHD. Results: Serum levels of sCD30 and serum IgE levels were significantly higher (p values <0.05) in patients with acute and chronic GVHD than in healthy controls. We found that CD30+ T-cells are present in the skin of patients with GVHD. Conclusion: These results suggest that serum sCD30 levels may be helpful for the management of patients with bone marrow transplantation. © 2013 Springer-Verlag Italia.
CITATION STYLE
Amedei, A., Pimpinelli, N., Grassi, A., Bella, C. D., Niccolai, E., Brancati, S., … D’Elios, M. M. (2014). Skin CD30+ T cells and circulating levels of soluble CD30 are increased in patients with graft versus host disease. Autoimmunity Highlights, 5(1), 21–26. https://doi.org/10.1007/s13317-013-0054-7
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