Excess weight and depression associated with serotonin transporter gene polymorphism (5-HTTLPR): A systematic review

Abstract

Background: Excess weight and depression have been studied due to the high prevalence in the population, the evidence indicates that there is a bidirectionality of origin and development of these diseases. Additionally, genetic load has been significantly associated in these diseases, an example is the polymorphism of the promoter region of the serotonin transporter gene (5-HTTLPR), studies report that this genetic factor can condition and aggravate the symptoms present in both conditions. Objective: Collect, review, and analyze published studies of the relationship between 5-HTTLPR polymorphism for the development of depression in overweight-obese people. Methods: Using the PRISMA checklist guidelines, a systematic search was performed in the databases: PubMed, Scopus, Web of Science (Science Citation Index Expanded and Social Sciences Citation Index) and EBSCO (Academic Search Complete, Fuente Académica and MedicLatina). The Web 3.0 platform: Critical Reading Files was used to analyze the quality of the studies Results: Seven studies were included, which provided evidence of the relationship between 5-HTTLPR polymorphism, depression and increased BMI / overweight-obesity. Conclusion: The evidence analyzed shows that the 5-HTTLPR polymorphism is linked to the development and symptoms of depression and obesity. Information that health personnel must consider in order to carry out treatments and care plans according to the needs of individuals with these conditions.