Heterochromia in designed metallopeptides: Geometry-selective binding of CdII in a de novo peptide

Abstract

Molecular recognition and control of the physical properties of metal ions are major challenges in metalloprotein design. The newly designed peptide Grand L16PenL26AL30C binds two CdII ions, each with a different coordination geometry - trigonal planar or pseudotetrahedral (see picture; Cd purple, S yellow, O blue). The physical properties of the two centers, such as site selectivity and pH dependence of binding, differ as well. (Graph Presented) © 2007 Wiley-VCH Verlag GmbH &. Co. KGaA.