Alterations in pre-mRNA splicing can have profound effects on gene expression and lead to cellular transformation. Oligonucleotide therapeutics are drugs that manipulate gene expression and improve the disease state. Antisense oligonucleotides hybridize with a target mRNA to downregulate gene expression via an RNase H-dependent mechanism. Additionally, RNase H-independent splice switching oligonucleotides (SSO) modulate alternative or aberrant splicing, to favor the therapeutically relevant splicing product. This chapter summarizes the progress made in the application of these oligonucleotide drugs in the treatment of cancer. © 2013 Springer-Verlag Berlin Heidelberg.
CITATION STYLE
Wan, J., Bauman, J. A., Graziewicz, M. A., Sazani, P., & Kole, R. (2013). Oligonucleotide therapeutics in cancer. Cancer Treatment and Research, 213–233. https://doi.org/10.1007/978-3-642-31659-3_9
Mendeley helps you to discover research relevant for your work.