Particular attention has been paid to capillary electrophoresis as versatile and environmentally friendly approach for enantioseparations of a wide spectrum of compounds. Cyclodextrin-modified micellar electrokinetic chromatography (CD-MEKC) is a method of choice to provide effective separation toward hydrophobic and uncharged stereoisomers. The chiral discrimination of the solutes relies upon the partitioning between a given CD in the aqueous phase and micelles formed from a surfactant. Synergistic combinations of chiral selectors, surfactant, and modifier contribute to successful enantioseparations of the enantiomers. In this chapter, an application of CD-MEKC for the enantioseparation of selected imidazole drugs employing a dual CDs system is described.
CITATION STYLE
Ibrahim, W. A. W., Wahib, S. M. A., Hermawan, D., & Sanagi, M. M. (2019). Enantioseparation of selected imidazole drugs using dual cyclodextrin-modified micellar electrokinetic chromatography. In Methods in Molecular Biology (Vol. 1985, pp. 407–416). Humana Press Inc. https://doi.org/10.1007/978-1-4939-9438-0_24
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