Bioinformatic approaches for identification of A-to-I editing sites

Abstract

The first discoveries of mammalian A-to-I RNA editing have been serendipitous. In conjunction with the fast advancement in sequencing technology, systematic methods for prediction and detection of editing sites have been developed, leading to the discovery of thousands of A-to-I editing sites. Here we review the state-of-the-art of these methods and discuss future directions. © 2011 Springer-Verlag Berlin Heidelberg.