Nephroprotective role of nanoencapsulated Tinospora cordifolia (Willd.) using polylactic acid nanoparticles in streptozotocin-induced diabetic nephropathy rats

Abstract

Currently, the field of nanomedicine, which uses active compounds from medicinal plants, has emerged as a therapy for diabetic nephropathy. From this study, the renoprotective effect of TC-loaded PLA Nanoparticles (TC-PLA NPs) on streptozotocin (STZ)-induced diabetic nephropathy rats was investigated. The results showed that the nephroprotective effect of TC-PLA NPs reduces the blood glucose level, regulates the renal parameters, decreases the cytokine levels and reduces the mRNA expressions level of different genes related to diabetic nephropathy.