Putting the Brake on Inflammatory Responses: The Role of Glucocorticoids

55Citations
Citations of this article
64Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Glucocorticoids are among the most widely used agents for the treatment of inflammatory diseases. The primary mechanism of glucocorticoid action is via the glucocorticoid receptor (GR), which blocks the expression of proinflammatory cytokines and adhesion molecules. Repression of many pro-inflammatory genes occurs by inhibition of transcription factors including nuclear factor κB (NFκB) and activator protein-1 (AP-1). In this article, we discuss the physiological and molecular interaction that occurs between GR and proinflammatory cytokines signaling pathways.

Cite

CITATION STYLE

APA

Hermoso, M. A., & Cidlowski, J. A. (2003). Putting the Brake on Inflammatory Responses: The Role of Glucocorticoids. IUBMB Life. https://doi.org/10.1080/15216540310001642072

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free