Fatal hemorrhagic gastrointestinal angioectasia after bone marrow transplantation for dyskeratosis congenita

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Abstract

Dyskeratosis congenita (DC) is a rare inherited disease in which the telomere complex cannot be maintained. Shortened telomeres can cause a number of clinical conditions. We herein report a case of unrelated bone marrow transplantation due to aplastic anemia associated with DC. The patient died of uncontrollable refractory intestinal bleeding. Three cases of DC with life-threatening hemorrhaging after transplantation have been reported; however, the bleeding origin could not be determined. Our case is the only patient in which a gastrointestinal bleeding point, jejunal multiple angioectasia, was determined.

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Imai, J., Suzuki, T., Yoshikawa, M., Dekiden, M., Nakae, H., Nakahara, F., … Mine, T. (2016). Fatal hemorrhagic gastrointestinal angioectasia after bone marrow transplantation for dyskeratosis congenita. Internal Medicine, 55(23), 3441–3444. https://doi.org/10.2169/internalmedicine.55.7462

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