This chapter describes the generation of the data in the CATH-Gene3D online resource and how it can be used to study protein domains and their evolutionary relationships. Methods will be presented for: comparing protein structures, recognizing homologs, predicting domain structures within protein sequences, and subclassifying superfamilies into functionally pure families, together with a guide on using the webpages.
CITATION STYLE
Dawson, N. L., Sillitoe, I., Lees, J. G., Lam, S. D., & Orengo, C. A. (2017). CATH-Gene3D: Generation of the resource and its use in obtaining structural and functional annotations for protein sequences. In Methods in Molecular Biology (Vol. 1558, pp. 79–110). Humana Press Inc. https://doi.org/10.1007/978-1-4939-6783-4_4
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