Differences in accuracy of99mTc-sestamibi scanning between severe and mild forms of primary hyperparathyroidism

22Citations
Citations of this article
13Readers
Mendeley users who have this article in their library.

Abstract

Preoperative localization of the parathyroids using 99mTc- sestamibi scanning has not yet been established as a routine diagnostic procedure for primary hyperparathyroidism. Several studies have demonstrated a variable degree of accuracy (70%-98%) in asymptomatic patients. Methods: We evaluated the accuracy of this technique in 64 patients who underwent scanning between January 2000 and January 2005 according to the clinical manifestations of the disease. Results: The study included 25 asymptomatic patients (group I), 18 nephrolithiasis patients without overt bone disease (group II), and 21 patients with severe bone involvement and osteitis fibrosa cystica (group III). Mean serum calcium in groups I, II, and III was 10.98 ± 0.02, 11.32 ± 0.17, and 13.35 ± 0.35 mg/dL, respectively. Mean serum parathyroid hormone in groups I, II, and III was 135.45 ± 13.50, 165.85 ± 15.06, and 579.6 ± 628.4 pg/mL, respectively. The 99mTc-sestamibi scan results were positive in 64% of the patients in group I, in 83% of those in group II, and in 100% of those in group III. Of the patients with severe bone disease, 70% showed increased uptake on the initial images, whereas in the other groups, increased uptake was seen only on the delayed images, as expected. Conclusion: Our data show a high degree of accuracy for the use of 99mTc-sestamibi scanning as a localizing procedure in severe primary hyperparathyroidism. COPYRIGHT © 2008 by the Society of Nuclear Medicine, Inc.

Cite

CITATION STYLE

APA

Bandeira, F. A. F., Oliveira, R. I. R. B., Griz, L. H. M., Caldas, G., & Bandeira, C. (2008). Differences in accuracy of99mTc-sestamibi scanning between severe and mild forms of primary hyperparathyroidism. Journal of Nuclear Medicine Technology, 36(1), 30–35. https://doi.org/10.2967/jnmt.107.044040

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free