Estimation of glomerular filtration rate in cynomolgus monkeys (Macaca fascicularis)

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Abstract

To estimate the glomerular filtration rate (GFR) in cynomolgus monkeys (Macaca fascicularis), a three-blood-sample method using iodixanol was assessed in comparison with the conventional multisample strategy using inulin. Iodixanol and inulin were coadministered intravenously 40 mg I/kg and 50 mg/kg, respectively, to male monkeys, followed by blood collection 60, 90 and 120 min later. A close correlation (r=0.96) was noted between the GFR values estimated by both methods. In clinically healthy monkeys, the basal values were determined to be 3.06 ± 0.50 ml/min/kg. This is the first report, suggesting that serum clearance of iodixanol is a ready-to-use tool for a screening the GFR in monkeys, although it is necessary to perform a more longitudinal study using animals with reduced renal function.

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Iwama, R., Sato, T., Sakurai, K., Takasuna, K., Ichijo, T., Furuhama, K., & Satoh, H. (2014). Estimation of glomerular filtration rate in cynomolgus monkeys (Macaca fascicularis). Journal of Veterinary Medical Science. Japanese Society of Veterinary Science. https://doi.org/10.1292/jvms.14-0218

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