Two studies tested the ability of metals and their salts to produce lung tumors in strain A mice. Of 13 compounds examined, lead subacetate, manganous sulfate, molybdenum trioxide, and nickelous acetate elicited a weakly carcinogenic response following intraperitoneal injection. Nine metallic compounds were negative. There was no evidence of cocarcinogenic effect between metals and the chemical carcinogen, 3-methylcholanthrene. On the basis of these and other data, recommendation is made for further investigations in metal carcinogenesis.
CITATION STYLE
Shimkin, M. B., Stoner, G. D., & Theiss, J. C. (1977). Lung tumor response in mice to metals and metal salts. Advances in Experimental Medicine and Biology, 91, 85–91. https://doi.org/10.1007/978-1-4684-0796-9_6
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