The contribution of reg family proteins to cell growth and survival in pancreatic islets

Abstract

In 2008, we have reviewed Reg family proteins which have been found and characterized in several systems including cell growth and regeneration in the pancreas. Since then the research scope has expanded significantly to the (patho-)physiology of the liver, intestine, immunity, and cancer. More importantly, in communicating our research findings, we feel the need of further classification in the family of seven independent genes and among key species. A more uniformed terminology should help us to understand their isoform-specific functions and/or mode of activation.