Brain perfusion CT compared with15O-H2O-PET in healthy subjects

Abstract

Background: Regional cerebral blood flow [rCBF] measurements are valuable for identifying angiogenically active tumours, and perfusion computed tomography [CT] has been suggested for that purpose. This study aimed to validate rCBF measurements by perfusion CT with positron-emission tomography [PET] and15O-labelled water [15OH2O] in healthy subjects. Methods: RCBF was measured twice in 12 healthy subjects with15O-H2O-PET and once with perfusion CT performed over the basal ganglia. Matching rCBF values in regions of interest were compared. Results: Measured with perfusion CT, rCBF was significantly and systematically overestimated. White matter rCBF values were 17.4 ± 2.0 (mean ± SD) mL min-1 100 g-1 for PET and 21.8 ± 3.4 mL min-1 100 g-1 for perfusion CT. Grey matter rCBF values were 48.7 ± 5.0 mL min-1 100 g-1 for PET and 71.8 ± 8.0 mL min-1 100 g-1 for perfusion CT. The overestimation of grey matter rCBF could be reduced from 47% to 20% after normalization to white matter rCBF, but the difference was still significant. Conclusion: RCBF measured with perfusion CT does contain perfusion information, but neither quantitative nor relative values can substitute rCBF measured by15O-H2O-PET yet. This, however, does not necessarily preclude a useful role in patient management. © 2011 Grüner et al.