Glutamatergic, Cholinergic, and GABAergic Systems in Posterior Cingulate Cortex: Interactions and Possible Mechanisms of Limbic System Disease

Abstract

review the organization of the glutaminergic system in cingulate cortex and evidence pertaining to the selective neurotoxic action of N-methyl-D-aspartate (NMDA) antagonists on anterior and posterior cingulate neurons / modulation of this toxicity by cholinergic and GABAergic systems is also considered / evidence is reviewed suggesting a link between the neurotoxic and psychotomimetic actions of these agents implications for mechanisms of memory / implications for psychotic disease processes / developmental hypothesis linking glutamate neurotoxicity to schizophrenia (PsycINFO Database Record (c) 2016 APA, all rights reserved)