Aberrant promoter methylation is a common mechanism for tumor suppressor inactivation in cancer. We develop a set of tools to identify genome-wide DNA methylation in distal regions with causal effect on tumorigenesis called MICMIC. Many predictions are directly validated by dCas9-based epigenetic editing to support the accuracy and efficiency of our tool. Oncogenic and lineage-specific transcription factors are shown to aberrantly shape the methylation landscape by modifying tumor-subtype core regulatory circuitry. Notably, the gene regulatory networks orchestrated by enhancer methylation across different cancer types are seen to converge on a common architecture. MICMIC is available on https://github.com/ZhangJlab/MICMIC.
CITATION STYLE
Tong, Y., Sun, J., Wong, C. F., Kang, Q., Ru, B., Wong, C. N., … Zhang, J. (2018). MICMIC: Identification of DNA methylation of distal regulatory regions with causal effects on tumorigenesis. Genome Biology, 19(1). https://doi.org/10.1186/s13059-018-1442-0
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