Application of novel methods in cancer therapy is important in terms of management and treatment of the life-threatening disorder. It appears that autophagy is a potential target in cancer therapy, as a variety of drugs targeting autophagy have shown great potential in reducing the viability and proliferation of cancer cells. Autophagy is primarily a catabolic process which provides energy during starvation. Besides, this process contributes to the degradation of aged or potentially toxic components and organelles. On the other hand, the source of a variety of naturally occurring anti-tumor drugs are flavonoids which have high anti-tumor activity. Luteolin is a polyphenolic flavone with the great pharmacological effects such as anti-diabetic, hepatoprotective, antioxidant, anti-inflammation, and anti-tumor. At the present review, we demonstrate how luteolin affects on autophagy process to induce anti-tumor activity.
CITATION STYLE
Ashrafizadeh, M., Ahmadi, Z., Farkhondeh, T., & Samarghandian, S. (2020, December 1). Autophagy regulation using luteolin: new insight into its anti-tumor activity. Cancer Cell International. BioMed Central Ltd. https://doi.org/10.1186/s12935-020-01634-9
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