Glucose regulates hypothalamic long-chain fatty acid metabolism via AMP-activated kinase (AMPK) in neurons and astrocytes

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Abstract

Background: Hypothalamic long-chain fatty acids (LCFA) and glucose are critical for energy balance, but it is not known if their metabolism is coupled. Results: Glucose regulates hypothalamic metabolism of palmitate via AMP-activated kinase. Conclusion: Glucose and LCFA metabolism is coupled in a cell-type and LCFA-dependent manner. Significance: This is the first evidence for glucose regulation of LCFA metabolic fate in the hypothalamus. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

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Taïb, B., Bouyakdan, K., Hryhorczuk, C., Rodaros, D., Fulton, S., & Alquier, T. (2013). Glucose regulates hypothalamic long-chain fatty acid metabolism via AMP-activated kinase (AMPK) in neurons and astrocytes. Journal of Biological Chemistry, 288(52), 37216–37229. https://doi.org/10.1074/jbc.M113.506238

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