Glucose regulates hypothalamic long-chain fatty acid metabolism via AMP-activated kinase (AMPK) in neurons and astrocytes

Abstract

Background: Hypothalamic long-chain fatty acids (LCFA) and glucose are critical for energy balance, but it is not known if their metabolism is coupled. Results: Glucose regulates hypothalamic metabolism of palmitate via AMP-activated kinase. Conclusion: Glucose and LCFA metabolism is coupled in a cell-type and LCFA-dependent manner. Significance: This is the first evidence for glucose regulation of LCFA metabolic fate in the hypothalamus. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.