Interleukin-18 induces insulin resistance in the hyperthyroid state

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Abstract

We previously reported that serum interleukin-18 (IL-18) levels were significantly increased in hyperthyroid Graves' disease patients. The development of insulin resistance in hyperthyroidism has been documented. We investigated the relationship between IL-18 and insulin resistance in patients with hyperthyroid Graves' disease and in experimental hyperthyroid mice. Then, we examined whether IL-18 induces insulin resistance in mice injected with IL-18 for a week. A significant positive correlation was observed between serum IL-18 levels and parameters such as thyroid functions and homeostasis model assessment for insulin resistance in hyperthyroid Graves' disease. In experimental hyperthyroid mice, IL-18 was significantly elevated. Insulin resistance increased in experimental hyperthyroid mice and IL-18-injected mice. These findings suggest IL-18 to be an important factor inducing insulin resistance in hyperthyroidism. © The Japan Endocrine Society.

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Miyauchi, S., Matsuura, B., Ueda, T., Eguchi, T., Tamaru, M., Yamamoto, S., … Onji, M. (2013). Interleukin-18 induces insulin resistance in the hyperthyroid state. Endocrine Journal, 60(4), 449–455. https://doi.org/10.1507/endocrj.ej12-0136

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