Erratum: Ago2 protects Drosophila siRNAs and microRNAs from target-directed degradation, even in the absence of 2'-O-methylation (RNA (2021) 27 (710-724) DOI: 10.1261/rna.078746.121)

Abstract

The authors would like to correct a recently identified error in which they inadvertently used unadjusted DESeq-derived P-values rather than values that had been adjusted for multiple-hypothesis testing. The correct Padj values are now reported in Supplemental Tables S1 and S3. With these corrections, the P-value threshold for calling significantly up-regulated miRNAs shifts from 10-8 to 2 × 10-7 in Supplemental Figure S1A and from <10-5 to <10-3 in Figure 3C. In addition, the numbers of siRNA loci called as significantly down- or up-regulated upon loss of Hen1 change from 84 and 25 to 39 and six, respectively, on page 717, top left column and in Figure 3D. In the Figure 1 legend, P < 10-8 has been corrected to P < 2 × 10-7. In the Figure 3 legend, P < 10-5 has been corrected to P < 10-3. These corrections do not impact any of the other results of the paper, and, importantly, do not impact any conclusions of the paper. The authors apologize for any inconvenience this may have caused. This article has been corrected online and in the Revised Supplemental Material.