Follow-up of natural products isolation refers to re-isolation of compound(s) of interest in larger amounts for further pharmacological testing, conclusive structure elucidation, structure modifications to synthesize analogs for structure-activity relationships (SAR) studies, preformulation and formulation studies or clinical trials. In addition to conventional synthetic chemistry approaches, several other methodologies can be applied for following-up natural products isolation. This chapter outlines, with specific examples, various strategies and methods involved in follow-up of natural products isolation. © 2012 Springer Science+Business Media, LLC.
CITATION STYLE
Cannell, R. J. P., Sarker, S. D., & Nahar, L. (2012). Follow-up of natural products isolation. Methods in Molecular Biology, 864, 473–514. https://doi.org/10.1007/978-1-61779-624-1_19
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