Investigation of Anti-hyperglycemic, Anti-allergic activities of ethanolic extract from Brownlowia tersa (L.) stem

Abstract

Brownlowia tersa (L.) (Family: Malvaceae), has been used traditionally to treat inflammation, pain, diarrhea, allergic reaction etc. The aim of the recent study is to investigate the ethanolic extract of Brownlowia tersa (L.) stem for its anti-hyperglycemic and anti-allergic activity as well as to identify the phytochemicals constituents. Blood glucose level in mice, in anti-hyperglycemic activity, evaluated by OGTT (oral glucose tolerance test) considerably reduced by the extract at both dose 250 and 500 mg/kg b. wt. The extract also decreased significantly the allergic-like symptoms like sneezing, scratching, and nasal score induced by TDI in mice model. The count of WBC (total and differential) in both blood and Bronchoalveolar lavage (BAL) fluid were also reduced in the extract treated group. In qualitative phytochemical investigation, existence of different bioactive phytochemicals like alkaloids, flavonoids, steroids and tannins were observed. So the investigation suggests the anti-hyperglycemic and anti-allergic activity of B. tersa stem extract due to the availability of one or more active metabolites in it.