Members of the p120-catenin family associate with cadherins and regulate their stability at the plasma membrane. How p120-catenin limits cadherin endocytosis has long remained a mystery. In this issue, Nanes et al. (2012. J. Cell Biol. doi:10.1083/jcb.201205029) identify a conserved acidic motif within cadherins that acts as a physical platform for p120-catenin binding. However, in the absence of p120-catenin, the motif acts as an endocytic signal. These results provide new insight into p120-catenin's role as guardian of intercellular junction dynamics. © 2012 Perez-Moreno and Fuchs.
CITATION STYLE
Perez-Moreno, M., & Fuchs, E. (2012). Guilt by association: What p120-catenin has to hide. Journal of Cell Biology, 199(2), 211–214. https://doi.org/10.1083/jcb.201209014
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