Calcium (Ca2+) homeostasis is fundamental for cell metabolism, proliferation, differentiation, and cell death. Elevation in intracellular Ca2+concentration is dependent either on Ca2+influx from the extracellular space through the plasma membrane, or on Ca 2+release from intracellular Ca2+stores, such as the endoplasmic/sarcoplasmic reticulum (ER/SR). Mitochondria are also major components of calcium signalling, capable of modulating both the amplitude and the spatio-temporal patterns of Ca2+signals. Recent studies revealed zones of close contact between the ER and mitochondria called MAMs (Mitochondria Associated Membranes) crucial for a correct communication between the two organelles, including the selective transmission of physiological and pathological Ca2+signals from the ER to mitochondria. In this review, we summarize the most up-to-date findings on the modulation of intracellular Ca2+release and Ca2+ uptake mechanisms. We also explore the tight interplay between ER- and mitochondria-mediated Ca 2+signalling, covering the structural and molecular properties of the zones of close contact between these two networks. © 2011 Patergnani et al; licensee BioMed Central Ltd.
CITATION STYLE
Patergnani, S., Suski, J. M., Agnoletto, C., Bononi, A., Bonora, M., De Marchi, E., … Pinton, P. (2011). Calcium signaling around Mitochondria Associated Membranes (MAMs). Cell Communication and Signaling. https://doi.org/10.1186/1478-811X-9-19
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