N-Acetyltransferase 2 (NAT2) genotyping by PCR and RFLP-based methods provides information on seven single nucleotide polymorphisms (SNPs) without deriving the chromosomal phase (haplotype). So genotyping results must be processed to get all possible NAT2 haplotype (or allele) combinations. Here we describe the procedure for genotyping and present a program based on Microsoft® Access® which automatically generates all possible haplotype pairs for a given unphased NAT2 genotype. NAT2 haplotypes are important to predict the NAT2 phenotype.
CITATION STYLE
Michael, G., Thier, R., Blaszkewicz, M., Selinski, S., & Golka, K. (2018). Algorithm for the automated evaluation of NAT2 genotypes. In Methods in Molecular Biology (Vol. 1655, pp. 77–96). Humana Press Inc. https://doi.org/10.1007/978-1-4939-7234-0_7
Mendeley helps you to discover research relevant for your work.