Fibroblast growth factor (FGF)-21, a member of the FGF family, is a novel hormone involved in the control of metabolism by modulating glucose homeostasis, insulin sensitivity, ketogenesis, and promoting adipose tissue “browning.” Recent studies demonstrated that brown adipose tissue is not only a target for FGF-21, but is also a potentially important source of systemic FGF-21. These findings support the hypothesis that FGF-21 plays a physiologic role in thermogenesis and thermogenic recruitment of white adipose tissue by an autocrine–paracrine axis. This review examines the role of FGF-21 in thermogenesis from the perspective of cell-based, animal model, and human studies. We also present recent advances in the characterization of FGF-21’s regulation of metabolism.
CITATION STYLE
Ni, B., Farrar, J. S., Vaitkus, J. A., & Celi, F. S. (2015, September 25). Metabolic Effects of FGF-21: Thermoregulation and Beyond. Frontiers in Endocrinology. Frontiers Media S.A. https://doi.org/10.3389/fendo.2015.00148
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