Effect of Turmeric Rhizome Extract (Curcuma longa L.) on Liver Histology of Preeclampsia Rat (Rattus norvegicus L.)

Abstract

Turmeric is usually consumed routinely and for a long time, so it cannot be ascertained that the use of turmeric is safe or toxic especially in the liver because there are as many as 64 compounds in turmeric which are thought to be hepatotoxic, The prevalence of preeclampsia is around 5% -15% of all pregnancies in the world, where cases of hypertension in pregnancy including preeclampsia are found in numbers that tend to increase and are the most common medical complication in pregnancy. About 70% of women diagnosed with hypertension in pregnancy are cases of preeclampsia. This study used a type of analytic research with quasi-experimental design in pregnant female rats consisting of 4 treatments with 6 replications each. This study consisted of a negative control group (k-) with only feed given ad libitum, positive control (k +) in injection of LPS intervena with a group dose of 0.2 / kgBW and a group giving turmeric extract (Curcuma longa L.) with doses of 400mg / kgBW (P1) and 600mg / kgBW (P2) respectively. After that, histological preparations were carried out on the liver of rats (Rattusnovergicus). From the results of observations of the liver morphology in the negative (-) and P2 treatment the liver color was found to be dark red, whereas in the positive control group (k +) a pale red color was found. Then histological observations showed an increase in the percentage of liver necrosis from P1 and a decrease in necrosis in P2.