Fungal endophthalmitis is a rare condition often associated with poor prognosis. We present a case of postoperative acute fungal endophthalmitis caused by the yeast-like fungus Stephanoascus ciferrii (Candida ciferrii). The fungus was resistant to fluconazole, voriconazole, and amphotericin B but susceptible to caspofungin. Because the degree of vitreal penetration of caspofungin after its intravenous administration is unclear, we performed multiple intravitreal injections, first with 50 μg/0.1 ml and then with 250 μg/0.1 ml caspofungin. Despite the recurrence of symptoms, intravitreal injection of caspofungin finally abolished the inflammation and achieved ambulatory vision that persisted until 1 year of follow-up. To our knowledge, this is the first report of S. ciferrii endophthalmitis and its successful treatment with intravitreal caspofungin.
CITATION STYLE
Danielescu, C., Cantemir, A., & Chiselita, D. (2017). Successful treatment of fungal endophthalmitis using intravitreal caspofungin. Arquivos Brasileiros de Oftalmologia, 80(3), 196–198. https://doi.org/10.5935/0004-2749.20170048
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