Targeting transcriptional factors in gastrointestinal cancers and future prospective

Abstract

Transcription factors (TFs) are deregulated in the majority of human cancers and play a major role in tumor progression and metastasis. Targeting TFs could prove to be highly effective in the treatment of gastrointestinal (GI) malignancies, as highlighted by the clinical efficiency of target molecules aiming at the nuclear hormone receptors. In this chapter, we summarize the role of different TFs discussed in the previous chapters with a focus on the emerging chemical as well as phytochemical approaches to control their functions. The outstanding diversity and efficacy of TFs as the driving force of cell transformation demands a continued search of TFs as novel and therapeutic agents for anti-GI treatments.