Biocompatibility and surface properties of hydrogenated amorphous silicon-germanium thin films prepared by LF-PECVD

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Abstract

We studied the surface morphology and biocompatibility of hydrogenated amorphous silicon-germanium (a-Si1-xGex:H) thin films prepared by Low Frequency Plasma Enhanced Chemical Vapor Deposition (LF-PECVD). These films were deposited on a Corning 2947 glass substrate having a thickness of 3 μm, the electrical performance showed a decreased electrical resistance for low regime voltage. The root mean square (RMS) surface roughness of the films was measured by atomic force microscopy (AFM) in a non-contact mode. A biocompatibility tests was carried out using primary cultures of dorsal root ganglion (DRG) of Wistar rats. The DRG neurons were incubated for 18 hours on a-Si1-xGex:H thin films, and subsequent electrophysiological recording was performed. These neurons displayed typical ionic currents, including a fast-inward current at the beginning of voltage clamp pulse (Na+ current) and ensuing outward currents (K+ current). In current clamp experiments, depolarizing current pulse injection caused typical action potential discharge of the neurons. These results confirmed the feasibility of using a-Si1-xGex:H thin films as a biocompatible material.

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Huerta, F. L., García, R. M. W., González, L. G., May, A. L. H., Arriaga, W. C., Vega, R., & Soto, E. (2019). Biocompatibility and surface properties of hydrogenated amorphous silicon-germanium thin films prepared by LF-PECVD. In IOP Conference Series: Materials Science and Engineering (Vol. 628). Institute of Physics Publishing. https://doi.org/10.1088/1757-899X/628/1/012003

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